FORMULATION AND EVALUATION OF PARENTERAL IN-SITU FORMING BIODEGRADABLE IMPLANT FOR CONTROLLED RELEASE OF LEVOTHYROXINE SODIUM

Objective: The objective of present research work is formulation and evaluation parenteral in-situ forming biodegradable implant for controlled release levothyroxine sodium. Material Method: study used N-Methyl pyrrolidone (NMP) triacetin as solvents PLGA a polymer to manufacture two polymeric drug delivery systems, (ISFI) micro particles (ISM). Other tests, such sterility, percent entrapment capacity, so on, were also carried out. ISFI ISM tested up one month at three different temperatures (4ºC, 25ºC, 40ºC). Result Discussions: from both systems was compared. content, type solvent (hydrophilic or hydrophobic), morphology all contributed increased burst in the formulation. Burst decreased using combination hydrophilic hydrophobic (NMP Triacetin). When compared other formulations, had lowest release. Both formulations might deliver medications 30 days. Long-acting Levothyroxine sodium (ISFI & ISM) may be superior option hypothyroidism treatment. Keyword: In-situ Implant, Biodegradable polymers, PLGA, Long term release, Solvent exchange technique, ISFI, ISM.